Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.

ABSTRACT:

Objective

Deficient cerebral inhibition is a pathophysiological brain deficit related to poor sensory gating and attention in schizophrenia and other disorders. Cerebral inhibition develops perinatally, influenced by genetic and in utero factors. Amniotic choline activates fetal α7-nicotinic acetylcholine receptors and facilitates development of cerebral inhibition. Increasing this activation may protect infants from future illness by promoting normal brain development. The authors investigated the effects of perinatal choline supplementation on the development of cerebral inhibition in human infants.

Method

A randomized placebo-controlled clinical trial of dietary phosphatidylcholine supplementation was conducted with 100 healthy pregnant women, starting in the second trime

SUBMITTER: Ross RG 

PROVIDER: S-EPMC3640283 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature