HIV-1 diversity in the envelope glycoproteins: implications for viral entry inhibition.

ABSTRACT: Entry of HIV-1 into a host cell is a multi-step process, with the viral envelope gp120 and gp41 acting sequentially to mediate the viral attachment, CD4 binding, coreceptor binding, and fusion of the viral and host membranes. The emerging class of antiretroviral agents, collectively known as entry inhibitors, interfere in some of these steps. However, viral diversity has implications for possible differential responses to entry inhibitors, since envelope is the most variable of all HIV genes. Different HIV genetic forms carry in their genomes genetic signatures and polymorphisms that could alter the structure of viral proteins which are targeted by drugs, thus impairing antiretroviral binding and efficacy. This review will examine current research that describes subtype differences in enve

SUBMITTER: Araujo LA 

PROVIDER: S-EPMC3640516 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature