Echocardiographic Characterization of Postnatal Development in Mice with Reduced Arterial Elasticity.

ABSTRACT:

Purpose

Decreased expression of elastin results in smaller, less compliant arteries and high blood pressure. In mice, these differences become more significant with postnatal development. It is known that arterial size and compliance directly affect cardiac function, but the temporal changes in cardiac function have not been investigated in elastin insufficient mice. The aim of this study is to correlate changes in arterial size and compliance with cardiac function in wildtype (WT) and elastin haploinsufficient (Eln^+/- ) mice from birth to adulthood.

Methods

Ultrasound scans were performed at the ages of 3, 7, 14, 21, 30, 60, and 90 days on male and female WT and Eln^+/- mice. 2-D ultrasound and pulse wave Doppler images were used to measur

SUBMITTER: Le VP 

PROVIDER: S-EPMC3640570 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature