Evidence of successful modulation of brain activation and subjective experience during reappraisal of negative emotion in unmedicated depression.

ABSTRACT: Functional magnetic resonance imaging (fMRI) was used to examine cognitive regulation of negative emotion in 12 unmedicated patients with major depressive disorder (MDD) and 24 controls. The participants used reappraisal to increase (real condition) and reduce (photo condition) the personal relevance of negative and neutral pictures during fMRI as valence ratings were collected; passive viewing (look condition) served as a baseline. Reappraisal was not strongly affected by MDD. Ratings indicated that both groups successfully reappraised negative emotional experience. Both groups also showed better memory for negative vs. neutral pictures 2 weeks later. Across groups, increased brain activation was observed on negative/real vs. negative/look and negative/photo trials in left dorsolateral pr

SUBMITTER: Dillon DG 

PROVIDER: S-EPMC3640775 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature