Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study.

ABSTRACT:

Purpose

Lung cancer in never-smokers (LCINS) is increasingly recognized as a distinct disease from that in ever-smokers owing to substantial differences in etiology, clinical characteristics, and prognosis. Therefore, we aimed to identify prognostic markers specific for LCINS.

Experimental design

First, 11,930 single-nucleotide polymorphisms (SNP) in 904 inflammation-related genes were genotyped, and their associations with overall survival in 411 patients with LCINS at MD Anderson Cancer Center were analyzed. Next, validation of the top 27 SNPs in 311 patients with LCINS at Mayo Clinic was conducted.

Results

Three SNPs (IL17RA:rs879576, BMP8A:rs698141, and STY:rs290229) were validated (P < 0.05), and two SNPs (CD74:rs1056400 and CD38:rs10805347) reached borderline si

SUBMITTER: Pu X 

PROVIDER: S-EPMC3640870 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature