A comparative proteomic study identified calreticulin and prohibitin up-regulated in adrenocortical carcinomas.

ABSTRACT:

Background

Identifying novel tumor biomarkers to develop more effective diagnostic and therapeutic strategies for patients with ACC is urgently needed. The aim of the study was to compare the proteomic profiles between adrenocortical carcinomas (ACC) and normal adrenocortical tissues in order to identify novel potential biomarkers for ACC.

Methods

The protein samples from 12 ACC tissues and their paired adjacent normal adrenocortical tissues were profiled with two-dimensional electrophoresis; and differentially expressed proteins were identified by mass spectrometry. Expression patterns of three differently expressed proteins calreticulin, prohibitin and HSP60 in ACC, adrenocortical adenomas (ACA) and normal adrenocortical tissues were further validated by immunohistochemist

SUBMITTER: Yang MS 

PROVIDER: S-EPMC3640901 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature