Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.

ABSTRACT: White blood cell count (WBC) is unique among identified inflammatory predictors of chronic disease in that it is routinely measured in asymptomatic patients in the course of routine patient care. We led a genome-wide association analysis to identify variants associated with WBC levels in 13,923 subjects in the electronic Medical Records and Genomics (eMERGE) Network. We identified two regions of interest that were each unique to subjects of genetically determined ancestry to the African continent (AA) or to the European continent (EA). WBC varies among different ancestry groups. Despite being ancestry specific, these regions were identifiable in the combined analysis. In AA subjects, the region surrounding the Duffy antigen/chemokine receptor gene (DARC) on 1q21 exhibited significant assoc

SUBMITTER: Crosslin DR 

PROVIDER: S-EPMC3640990 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature