Employment-based reinforcement of adherence to oral naltrexone treatment in unemployed injection drug users.

ABSTRACT: Oral naltrexone has high potential for use as a relapse prevention pharmacotherapy for opiate dependence yet suffers from notoriously poor adherence. This study evaluated whether entry to a therapeutic workplace could reinforce adherence with oral naltrexone. Opiate-dependent and cocaine-using injection drug users were detoxified, inducted onto oral naltrexone, and randomly assigned to a contingency (n = 35) or prescription (n = 32) group for a 26-week period. Contingency participants were required to ingest naltrexone under staff observation to gain access to the therapeutic workplace. Prescription participants received a take-home supply of naltrexone and could access the workplace independent of naltrexone ingestion. Primary outcome measures were percent of urine samples positive for na

SUBMITTER: Dunn KE 

PROVIDER: S-EPMC3641088 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature