Unique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control.

ABSTRACT: Quetiapine is an atypical neuroleptic with a pharmacological profile distinct from classic neuroleptics that function primarily via blockade of dopamine D2 receptors. In the United States, quetiapine is currently approved for treating patients with schizophrenia, major depression and bipolar I disorder. Despite its widespread use, its cellular effects remain elusive. To address possible mechanisms, we chronically treated mice with quetiapine, haloperidol or vehicle and examined quetiapine-specific gene expression change in the frontal cortex. Through microarray analysis, we observed that several groups of genes were differentially expressed upon exposure to quetiapine compared with haloperidol or vehicle; among them, Cdkn1a, the gene encoding p21, exhibited the greatest fold change relativ

SUBMITTER: Kondo MA 

PROVIDER: S-EPMC3641406 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature