Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection.

ABSTRACT:

Background

Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using integrated databases.

Methods

From September 2006 to May 2011, strains isolated from Clostridium difficile toxin enzyme immunoassay (EIA)-positive fecal samples from Oxfordshire, United Kingdom (approximately 600,000 people) underwent multilocus sequence typing. Fourteen-day mortality and levels of 15 baseline biomarkers were compared between consecutive C. difficile infections (CDIs) from different clades/sequence types (STs) and EIA-negative controls using Cox and normal regression adjusted for demographic/clinical factors.

Results

Fourteen-day mortality was 13% in 2222 adults with 2745 EIA-positive samples (medi

SUBMITTER: Walker AS 

PROVIDER: S-EPMC3641870 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature