Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome.

ABSTRACT:

Background

A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes.

Objective

This study hypothesized that risk assessment in LQTS patients should incorporate genotype-specific QT correction for heart rate.

Methods

The independent contribution of 4 repolarization measures (the absolute QT interval, and Bazett's, Fridericia's, and Framingham's correction formulas) to the risk of aborted cardiac arrest or sudden cardiac death during adolescence, before and after further adjustment for the RR interval, was assessed in 727 LQTS type 1 and 582 LQTS type 2 patients. Improved QT/RR correction was calculated using a Cox model, divid

SUBMITTER: Barsheshet A 

PROVIDER: S-EPMC3641882 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature