Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters.

ABSTRACT:

Background

The transformation of a developing epithelium into an adult structure is a complex process, which often involves coordinated changes in cell proliferation, metabolism, adhesion, and shape. To identify genetic mechanisms that control epithelial differentiation, we analyzed the temporal patterns of gene expression during metamorphosis of the Drosophila wing.

Results

We found that a striking number of genes, approximately 50% of the Drosophila transcriptome, exhibited changes in expression during a time course of wing development. While cis-acting enhancer sequences clearly correlated with these changes, a stronger correlation was discovered between core-promoter types and the dynamic patterns of gene expression within this differentiating tissue. In support of the h

SUBMITTER: O'Keefe DD 

PROVIDER: S-EPMC3641971 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature