Stress and gene expression of individuals with chronic abdominal pain.

ABSTRACT:

Background

Research examining the role of stress in gastrointestinal (GI) symptoms such as chronic abdominal pain (CAP) is controversial. The purpose of this study was to examine the expression of genes involved in metabolic stress and toxicity in men and women with high and low levels of perceived stress with and without CAP.

Methods

Data and samples were collected and the expression of genes involved in metabolic stress and toxicity was analyzed in 26 individuals who had consented to participate in a natural history protocol. Subjects completed the 10-item Perceived Stress scale (PSS). Fasting participants' peripheral whole blood was collected for proteomic and genomic studies. Polymerase chain reaction (PCR) array was used to analyze the expression of 84 key genes involve

SUBMITTER: Peace RM 

PROVIDER: S-EPMC3642034 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature