Extensive circadian and light regulation of the transcriptome in the malaria mosquito Anopheles gambiae.

ABSTRACT:

Background

Mosquitoes exhibit 24 hr rhythms in flight activity, feeding, reproduction and development. To better understand the molecular basis for these rhythms in the nocturnal malaria vector Anopheles gambiae, we have utilized microarray analysis on time-of-day specific collections of mosquitoes over 48 hr to explore the coregulation of gene expression rhythms by the circadian clock and light, and compare these with the 24 hr rhythmic gene expression in the diurnal Aedes aegypti dengue vector mosquito.

Results

In time courses from An. gambiae head and body collected under light:dark cycle (LD) and constant dark (DD) conditions, we applied three algorithms that detect sinusoidal patterns and an algorithm that detects spikes in expression. This revealed across four experime

SUBMITTER: Rund SS 

PROVIDER: S-EPMC3642039 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature