Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison.

ABSTRACT:

Objective

We conducted a systematic literature review with indirect comparison of studies evaluating therapeutic efficacy and toxicity associated to visceral leishmaniasis (VL) therapy among HIV infected individuals.

Main outcome measurements

The outcomes of interest were clinical and parasitological cure, mortality, and adverse events.

Methods

PRISMA guidelines for systematic reviews and Cochrane manual were followed. Sources were MEDLINE, LILACS, EMBASE, Web of Knowledge databases and manual search of references from evaluated studies. We included all studies reporting outcomes after VL treatment, regardless of their design. Study quality was evaluated systematically by using the Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta

SUBMITTER: Cota GF 

PROVIDER: S-EPMC3642227 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature