Confounding with familial determinants affects the association between mode of delivery and childhood asthma medication - a national cohort study.

ABSTRACT:

Background

Mode of delivery may affect the risk of asthma but the findings have not been consistent and factors shared by siblings may confound the associations in previous studies.

Methods

The association between mode of delivery and dispensed inhaled corticosteroid (ICS) (a marker of asthma) was examined in a register based national cohort (n=199 837). A cohort analysis of all first born children aged 2-5 and 6-9 years was performed. An age-matched sibling-pair analysis was also performed to account for shared genetic and environmental risk factors.

Results

Analyses of first-borns demonstrated that elective caesarean section was associated with an increased risk of dispensed ICS in both 2-5 (adjusted odds ratio (aOR)=1.19, 95% confidence interval (CI) 1.09-1.29) and

SUBMITTER: Braback L 

PROVIDER: S-EPMC3643829 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature