Genome-wide association study of sleep in Drosophila melanogaster.

ABSTRACT:

Background

Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown.

Results

We used the Drosophila Genetic Reference Panel (DGRP) to perform a genome-wide association (GWA) study of sleep in D. melanogaster. We identified candidate single nucleotide polymorphisms (SNPs) associated with differences in the mean as well as the environmental sensitivity of sleep traits; these SNPs typically had sex-specific or sex-biased effects, and were generally located in non-coding regions. The majority of SNPs (80.3%) affecting sleep were at low frequency and had moderately large effects. Additive models incorporating multiple SNPs explained as m

SUBMITTER: Harbison ST 

PROVIDER: S-EPMC3644253 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature