Effects of age on noninvasive assessments of vascular function in nonhuman primates: implications for translational drug discovery.

ABSTRACT:

Background

Endothelium-dependent flow mediated dilation (FMD) and pulse-wave velocity (PWV), are used as measures of vascular health and predictors of cardiovascular risk in clinical studies, and both are age-dependent. Numbers of circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs) are also associated with cardiovascular risk, but independent of age in humans. The use of these measurements for pre-clinical assessment of drug cardiovascular safety and efficacy in non-human primates (NHPs) may promote the translation of drug-induced effects on vascular function to clinic outcomes. However, in NHPs, the age effects on the non-invasive measurements of FMD and PWV and the relationship of EMPs/EPCs with FMD are unknown.

Methods

A non-invasive, cli

SUBMITTER: Knight DR 

PROVIDER: S-EPMC3644259 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature