Learning contextual gene set interaction networks of cancer with condition specificity.

ABSTRACT:

Background

Identifying similarities and differences in the molecular constitutions of various types of cancer is one of the key challenges in cancer research. The appearances of a cancer depend on complex molecular interactions, including gene regulatory networks and gene-environment interactions. This complexity makes it challenging to decipher the molecular origin of the cancer. In recent years, many studies reported methods to uncover heterogeneous depictions of complex cancers, which are often categorized into different subtypes. The challenge is to identify diverse molecular contexts within a cancer, to relate them to different subtypes, and to learn underlying molecular interactions specific to molecular contexts so that we can recommend context-specific treatment to patients

SUBMITTER: Jung S 

PROVIDER: S-EPMC3644282 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature