The association of fetal cerebrovascular resistance with early neurodevelopment in single ventricle congenital heart disease.

ABSTRACT:

Background

Children with congenital heart disease are at risk for impaired neurodevelopment (ND). We investigated the association of fetal cerebrovascular resistance with ND in patients with single ventricle lesions.

Methods

In the Single Ventricle Reconstruction (SVR) and Infant Single Ventricle trials, 14-month ND was assessed using the Bayley Scales of Infant Development II. We investigated associations between ND scores and fetal middle cerebral artery pulsatility index (MCA-PI) z-scores, a Doppler-derived estimate of cerebrovascular resistance in a subset of those infants.

Results

Neurodevelopment assessments were performed at age 14.3 ± 1 months in 170 (74%) of 230 Infant Single Ventricle and 321 (58%) of 555 SVR subjects. Fetal echocardiographic data were avail

SUBMITTER: Williams IA 

PROVIDER: S-EPMC3644301 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature