A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts.

ABSTRACT:

Objective

Factors responsible for the variability in outcomes after lower extremity vein bypass grafting (LEVBG) are poorly understood. Recent evidence has suggested that a single nucleotide polymorphism (SNP) in the promoter region of the p27(Kip1) gene, a cell-cycle regulator, is associated with coronary in-stent restenosis. We hypothesized an association with vein graft patency.

Methods

This was a retrospective genetic association study nested within a prospective cohort of 204 patients from three referral centers undergoing LEVBG for claudication or critical ischemia. The main outcome measure was primary vein graft patency.

Results

All patients were followed up for a minimum of 1 year with duplex graft surveillance (median follow-up, 893 days; interquartile range,

SUBMITTER: Conte MS 

PROVIDER: S-EPMC3644510 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature