Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study.

ABSTRACT:

Context

Premenopausal women with idiopathic osteoporosis (IOP) have abnormal cortical and trabecular bone microarchitecture.

Objective

The purpose of this study was to test the hypotheses that teriparatide increases bone mineral density (BMD) and bone formation and improves trabecular microarchitecture and stiffness in women with IOP.

Design

This was an open-label pilot study.

Setting

The setting was a tertiary care referral center.

Patients

Participants were 21 premenopausal women with unexplained fragility fractures or low BMD.

Intervention

Teriparatide was administered at 20 μg daily for 18 to 24 months.

Main outcome measures

The primary endpoint was within-subject percent change in lumbar spine BMD. Secondary endpoints included percent

SUBMITTER: Cohen A 

PROVIDER: S-EPMC3644608 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature