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EXclusion: toward integrating the X chromosome in genome-wide association analyses.


ABSTRACT: The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Studies (NHGRI GWAS Catalog). It will also investigate commonly cited reasons for exclusion of the X chromosome from GWAS and review the tools currently available for X chromosome analysis. It will conclude with recommendations for incorporating X chromosome analyses in future studies.

SUBMITTER: Wise AL 

PROVIDER: S-EPMC3644627 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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eXclusion: toward integrating the X chromosome in genome-wide association analyses.

Wise Anastasia L AL   Gyi Lin L   Manolio Teri A TA  

American journal of human genetics 20130501 5


The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Stud  ...[more]

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