Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.

ABSTRACT:

Context

Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.

Objective

To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.

Design, setting, and participants

Examination of 141 single-nucleotide polymorphisms in

SUBMITTER: Levin GP 

PROVIDER: S-EPMC3645444 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature