Environmental stresses induce misfolded protein aggregation in plant cells in a microtubule-dependent manner.

ABSTRACT: Misfolded protein aggregation in mammalian cells is one of the cellular responses to environmental stresses. However, the aggregation of misfolded proteins in plant cells exposed to environmental stresses is still poorly understood. Here, we report the misfolded protein aggregation in plant cells in response to environmental stresses, including ultraviolet (UV) radiation, heat stress and cold stress. Treatment of grape and tobacco cultured cells with MG-132, a proteasome inhibitor, induced misfolded protein aggregation. All of the environmental stresses examined induced the endoplasmic reticulum (ER) stress response in the cells. The cells under ER stress showed aggregation of misfolded proteins. The misfolded protein aggregation was completely inhibited by treatment of the cells with tric

SUBMITTER: Nakajima Y 

PROVIDER: S-EPMC3645715 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature