Role of UPR pathway in defense response of Aedes aegypti against Cry11Aa toxin from Bacillus thuringiensis.

ABSTRACT: The insecticidal Cry toxins are pore-forming toxins produced by the bacteria Bacillus thuringiensis that disrupt insect-midgut cells. Cells can trigger different survival mechanisms to counteract the effects of sub-lytic doses of pore forming toxins. Particularly, two signaling pathways have been demonstrated to play a role in the defense mechanism to other toxins in Caenorhabditis elegans and in mammalian cells. These are the unfolded protein response (UPR) and the sterol regulatory element binding proteins (SREBP) pathways, which are proposed to facilitate membrane repair responses. In this work we analyzed the role of these pathways in Aedes aegypti response to intoxication with Cry11Aa toxin. We show that UPR is activated upon toxin ingestion. The role of these two pathways was analyze

SUBMITTER: Bedoya-Perez LP 

PROVIDER: S-EPMC3645755 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature