The OMERACT core set of outcome measures for use in clinical trials of ANCA-associated vasculitis.

ABSTRACT: There has been a marked increase in the past 15 years in the number and quality of clinical trials in the idiopathic inflammatory vasculitides, especially the small-vessel vasculitides known as antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis [AAV; granulomatosis, with polyangiitis (Wegener's)]. These trials have been conducted by multicenter, international groups in Europe and the United States with financial support provided by government agencies and biopharmaceutical companies. This increased clinical trial activity in vasculitis has been accompanied by the development and validation of new outcome measures--a challenging process for these complex, multiorgan system diseases. The international OMERACT Vasculitis Working Group has developed and implemented an iterati

SUBMITTER: Merkel PA 

PROVIDER: S-EPMC3645858 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature