Zebrafish melanophilin facilitates melanosome dispersion by regulating dynein.

ABSTRACT:

Background

Fish melanocytes aggregate or disperse their melanosomes in response to the level of intracellular cAMP. The role of cAMP is to regulate both melanosome travel along microtubules and their transfer between microtubules and actin. The factors that are downstream of cAMP and that directly modulate the motors responsible for melanosome transport are not known. To identify these factors, we are characterizing melanosome transport mutants in zebrafish.

Results

We report that a mutation (allele j120) in the gene encoding zebrafish melanophilin (Mlpha) interferes with melanosome dispersion downstream of cAMP. Based on mouse genetics, the current model of melanophilin function is that melanophilin links myosin V to melanosomes. The residues responsible for this function a

SUBMITTER: Sheets L 

PROVIDER: S-EPMC3645937 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature