ClusCo: clustering and comparison of protein models.

ABSTRACT:

Background

The development, optimization and validation of protein modeling methods require efficient tools for structural comparison. Frequently, a large number of models need to be compared with the target native structure. The main reason for the development of Clusco software was to create a high-throughput tool for all-versus-all comparison, because calculating similarity matrix is the one of the bottlenecks in the protein modeling pipeline.

Results

Clusco is fast and easy-to-use software for high-throughput comparison of protein models with different similarity measures (cRMSD, dRMSD, GDT_TS, TM-Score, MaxSub, Contact Map Overlap) and clustering of the comparison results with standard methods: K-means Clustering or Hierarchical Agglomerative Clustering.

Conclusions<

SUBMITTER: Jamroz M 

PROVIDER: S-EPMC3645956 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature