Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories.

ABSTRACT:

Background

Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with µNS from orthoreoviruses, which are involved in the formation of viral factories.

Methodology/principal findings

In this study, the NS80 characteristics and its interactions with other viral components were investigated. We observed that the NS80 structure ensured its self-aggregation and selective recruitment of viral proteins to viral factories like structures (VFLS). The minimum amino acids (aa) of NS80 required for VFLS formation included 193 aa at the C-terminal. However, this truncated protein only contained one aa coil a

SUBMITTER: Ke F 

PROVIDER: S-EPMC3646018 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature