Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory.

ABSTRACT:

Background

Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailored inflammatory gene expression patterns. Monocytes, which produce pro-inflammatory mediators, are readily recruited to the central nervous system (CNS) in neurodegenerative diseases.

Methods

This study explored the expression of receptors (CD11b, TLR2 and TLR4) on circulating monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs) isolated from healthy elderly adults who we classified as either IQ memory-consistent (high-performing, HP) or IQ memory-discrepant (low-performi

SUBMITTER: Downer EJ 

PROVIDER: S-EPMC3646027 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature