Optimization of melanin production by Brevundimonas sp. SGJ using response surface methodology.

ABSTRACT: Melanins are predominantly indolic polymers which are extensively synthesized in animals, plants and microorganisms. It has wide applications in cosmetics, agriculture and medicine. In the present study, optimization of process parameters influencing melanin production was attempted using the response surface methodology (RSM) from Brevundimonas sp. SGJ. A Plackett-Burman design was used for screening of critical components, while further optimization was carried out using the Box-Behnken design. The optimum conditions observed were pH 5.31, tryptone 1.440 g l^-1, L-tyrosine 1.872 g l^-1 and CuSO₄ 0.0366 g l^-1. Statistical analysis revealed that the model is significant with model F value 29.03 and R² value 0.9667. The optimization of pr

SUBMITTER: Surwase SN 

PROVIDER: S-EPMC3646113 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature