Evaluating the expression of oct4 as a prognostic tumor marker in bladder cancer.

ABSTRACT:

Objectives

The key transcriptional regulator Oct4 is one of the self-renewal and differentiation-related factors in cancer stem cells, where it maintains "stemness" state. Cancer stem cells have been identified in a variety of solid malignancies. They are a small population of tumor cells with stem cell characteristics, which are a likely cause of relapse in cancer patients. Due to high incidence, mortality, and recurrence rates of bladder cancer and the necessity of accurate prediction of malignant behavior of the tumors, we evaluated the prognostic value of Oct4 expression in formalin-fixed paraffin-embedded (FFPE) tissues of bladder cancer.

Materials and methods

In this study, Oct4 expression was evaluated in 52 (FFPE) tissues of bladder cancer. RNA extraction from sample

SUBMITTER: Hatefi N 

PROVIDER: S-EPMC3646225 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature