A Stiff Injectable Biodegradable Elastomer.

ABSTRACT: Injectable materials often have shortcomings in mechanical and drug-eluting properties that are attributable to their high water contents. A water-free, liquid four-armed PEG modified with dopamine end groups is described which changed from liquid to elastic solid by reaction with a small volume of Fe³⁺ solution. The elastic modulus and degradation times increased with increasing Fe³⁺ concentrations. Both the free base and the water-soluble form of lidocaine could be dissolved in the PEG₄-dopamine and released in a sustained manner from the cross-linked matrix. PEG₄-dopamine was retained in the subcutaneous space in vivo for up to 3 weeks with minimal inflammation. This material's tailorable mechanical properties, biocompatibility, ability to inc

SUBMITTER: Mizrahi B 

PROVIDER: S-EPMC3646576 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature