An aquatic host-guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin.

ABSTRACT: We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host-guest complex with doxorubicin as evidenced by FRET experiments.

SUBMITTER: Rivera JM 

PROVIDER: S-EPMC3646657 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature