DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population.

ABSTRACT:

Introduction

DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation of CpG islands have been reported. Four groups of DNMTs have been identified: DNMT1, DNMT2 (TRDMT1), DNMT3A and DNMT3B. DNMT2 uses the catalytic mechanism of DNMTs, but does in fact methylate RNA. Little is known about the significance of these genes in human breast cancer. In the study presented herein, we analyzed five distinct DNMT single SNPs with regard to potential associations with breast cancer risk.

Case description

In this study, we genotyped 221 fem

SUBMITTER: Kullmann K 

PROVIDER: S-EPMC3646668 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature