Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.

ABSTRACT:

Objective

Multiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia.

Method

Based on the Lifetime Dimensions of Psychosis Scale ratings of 2,454 case subjects of European ancestry from the Molecular Genetics of Schizophrenia (MGS) sample, three symptom factors (positive, negative/disorganized, and mood) were identified with exploratory factor analysis. Quantitative scores for each factor from a confirmatory factor analysis were analyzed for association with 696,491 single-nucleotide polymorphisms (SNPs) using linear regression, with correction for age, sex, clinical site, and ancestry.

SUBMITTER: Fanous AH 

PROVIDER: S-EPMC3646712 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature