Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.

ABSTRACT: Fine-tuned Notch and Hedgehog signalling pathways via attenuators and dampers have long been recognized as important mechanisms to ensure the proper size and differentiation of many organs and tissues. This notion is further supported by identification of mutations in these pathways in human cancer cells. However, although it is common that the Notch and Hedgehog pathways influence growth and patterning within the same organ through the establishment of organizing regions, the cross-talk between these two pathways and how the distinct organizing activities are integrated during growth is poorly understood. Here, in an unbiased genetic screen in the Drosophila melanogaster eye, we found that tumour-like growth was provoked by cooperation between the microRNA miR-7 and the Notch pathway. Sur

SUBMITTER: Da Ros VG 

PROVIDER: S-EPMC3646720 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature