Propensity score estimation to address calendar time-specific channeling in comparative effectiveness research of second generation antipsychotics.

ABSTRACT:

Background

Channeling occurs when a medication and its potential comparators are selectively prescribed based on differences in underlying patient characteristics. Drug safety advisories can provide new information regarding the relative safety or effectiveness of a drug product which might increase selective prescribing. In particular, when reported adverse effects vary among drugs within a therapeutic class, clinicians may channel patients toward or away from a drug based on the patient's underlying risk for an adverse outcome. If channeling is not identified and appropriately managed it might lead to confounding in observational comparative effectiveness studies.

Objective

To demonstrate channeling among new users of second generation antipsychotics following a Food and D

SUBMITTER: Dusetzina SB 

PROVIDER: S-EPMC3646952 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature