Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer.

ABSTRACT:

Purpose

To quantify the impact of respiratory motion on the treatment of lung tumors with spot scanning proton therapy.

Methods and materials

Four-dimensional Monte Carlo simulations were used to assess the interplay effect, which results from relative motion of the tumor and the proton beam, on the dose distribution in the patient. Ten patients with varying tumor sizes (2.6-82.3 cc) and motion amplitudes (3-30 mm) were included in the study. We investigated the impact of the spot size, which varies between proton facilities, and studied single fractions and conventionally fractionated treatments. The following metrics were used in the analysis: minimum/maximum/mean dose, target dose homogeneity, and 2-year local control rate (2y-LC).

Results

Respiratory motion reduce

SUBMITTER: Grassberger C 

PROVIDER: S-EPMC3646997 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature