Dynamics of breast milk HIV-1 RNA with unilateral mastitis or abscess.

ABSTRACT:

Background

Mastitis and abscess in HIV-infected women increase the risk of breastfeeding transmission of HIV. Guidelines encourage women to stop breastfeeding on the affected breast and feed on the contralateral breast. However, impact of breast pathology on breast milk HIV dynamics is unknown.

Methods

HIV RNA was quantified in 211 breast milk samples collected before, during, and after a clinical mastitis or an abscess diagnosis from 38 HIV-infected women participating in a Zambian breastfeeding study. HIV RNA quantity was compared between affected and unaffected breasts over time using generalized estimating equation models. A sample of 115 women without breast pathology was selected as a control group.

Results

In the affected breast, breast milk HIV RNA quantity in

SUBMITTER: Semrau K 

PROVIDER: S-EPMC3647002 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature