Inflammation in the setting of chronic allograft dysfunction post-kidney transplant: phenotype and genotype.

ABSTRACT:

Background

Chronic allograft dysfunction (CGD) is a common outcome in kidney transplants, but its pathogenesis is unclear. We investigated the CGD phenotype and single-nucleotide polymorphisms (SNPs) associated with CGD.

Method

This prospective study enrolled 2336 transplants from seven transplant centers in North America. CGD was defined as a >25% rise in serum creatinine relative to a three-month post-transplant baseline, requiring a kidney biopsy. We genotyped 2724 SNPs in the initial 979 transplants, which form the test cohort.

Results

CGD occurred 11.2 times per 100 person-years at a median of 509 ± 387 days from the three-month baseline. CGD was independently associated with death-censored, allograft failure, in an adjusted analysis [HR=20.6 (11.8-35.8, p < 0.00

SUBMITTER: Israni AK 

PROVIDER: S-EPMC3647022 | biostudies-literature | 2013 May-Jun

REPOSITORIES: biostudies-literature