3' untranslated region 1630 C>T polymorphism of prohibitin increases risk of breast cancer.

ABSTRACT:

Background

Prohibitin 3' untranslated region 1630 C>T (rs6917) polymorphism creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. Previous studies indicate that women carrying the prohibitin T allele have an increased susceptibility to breast cancer. However, the role of 1630 C>T polymorphism in mRNA expression of prohibitin and its contribution to carcinogenesis in the breast remains controversial.

Methods

Using mRNA expression data from the HapMap online database, we sought an association between prohibitin 1630 C>T polymorphism and its mRNA expression, then conducted a meta-analysis of prohibitin 1630 C>T polymorphism and risk of breast cancer.

Results

Although no significant association was found between prohi

SUBMITTER: Tang L 

PROVIDER: S-EPMC3647329 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature