Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.

ABSTRACT: Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.

SUBMITTER: Bright AT 

PROVIDER: S-EPMC3647516 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature