The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells.

ABSTRACT:

Purpose

To investigate the relationship between cup-to-disc ratio (CDR) and estimates of retinal ganglion cell (RGC) number.

Methods

This cross-sectional study included 156 healthy eyes, 53 glaucoma suspects, and 127 eyes with glaucoma. All eyes had standard automated perimetry (SAP), Cirrus SD-OCT, and stereoscopic optic disc photography within 6 months. CDR was determined from stereoscopic photographs by two or more masked graders. The number of RGCs in each eye was estimated using a published model that combines estimates of RGC number from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer measurements.

Results

The mean estimated RGC count was 1,063,809 in healthy eyes; 828,522 in eyes with suspected glaucoma; and 774,200 in early, 468,568 in moderate

SUBMITTER: Tatham AJ 

PROVIDER: S-EPMC3648225 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature