Sodium nitroprusside is not associated with metabolic acidosis during intraoperative infusion in children.

ABSTRACT:

Background

Sodium nitroprusside (SNP) is a potent vasodilator that has been used to induce deliberate hypotension in children during surgery involving significant blood loss, including craniofacial and spinal fusion procedures. SNP metabolism liberates cyanide, which may cause interference with cellular energy metabolism, leading to metabolic acidosis and central nervous system injury. We performed a retrospective, case-control study to determine whether the short-term intra-operative use of SNP for deliberate hypotension is associated with metabolic acidosis in children undergoing surgical procedures for craniofacial or spinal anomalies. Cyanide and thiocyanate concentrations were also recorded in patients who received SNP.

Methods

Data from 166 children undergoing craniofa

SUBMITTER: Hammer GB 

PROVIDER: S-EPMC3648371 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature