Development of a population suppression strain of the human malaria vector mosquito, Anopheles stephensi.

ABSTRACT:

Background

Transgenic mosquito strains are being developed to contribute to the control of dengue and malaria transmission. One approach uses genetic manipulation to confer conditional, female-specific dominant lethality phenotypes. Engineering of a female-specific flightless phenotype provides a sexing mechanism essential for male-only mosquito, release approaches that result in population suppression of target vector species.

Methods

An approach that uses a female-specific gene promoter and antibiotic-repressible lethal factor to produce a sex-specific flightless phenotype was adapted to the human malaria vector, Anopheles stephensi. Transposon- and site-specific recombination-mediated technologies were used to generate a number of transgenic An. stephensi lines that when

SUBMITTER: Marinotti O 

PROVIDER: S-EPMC3648444 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature