Semiquantitative proteomic analysis of human hippocampal tissues from Alzheimer's disease and age-matched control brains.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common type of dementia affecting people over 65 years of age. The hallmarks of AD are the extracellular deposits known as amyloid β plaques and the intracellular neurofibrillary tangles, both of which are the principal players involved in synaptic loss and neuronal cell death. Tau protein and Aβ fragment 1-42 have been investigated so far in cerebrospinal fluid as a potential AD biomarkers. However, an urgent need to identify novel biomarkers which will capture disease in the early stages and with better specificity remains. High-throughput proteomic and pathway analysis of hippocampal tissue provides a valuable source of disease-related proteins and biomarker candidates, since it represents one of the earliest affected brain regions

SUBMITTER: Begcevic I 

PROVIDER: S-EPMC3648498 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature