Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis.

ABSTRACT:

Background

Somitogenesis is a fundamental characteristic feature of development in various animal embryos. Molecular evidence has proved that the Notch and Wnt pathways play important roles in regulating the process of somitogenesis and there is crosstalk between these two pathways. However, it is difficult to investigate the detailed mechanism of these two pathways and their interactions in somitogenesis through biological experiments. In recent years some mathematical models have been proposed for the purpose of studying the dynamics of the Notch and Wnt pathways in somitogenesis. Unfortunately, only a few of these models have explored the interactions between them.

Results

In this study, we have proposed three mathematical models for the Notch signalling pathway alone, th

SUBMITTER: Wang HY 

PROVIDER: S-EPMC3648501 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature