Alterations in circulating T-cell lymphocyte populations in children with obstructive sleep apnea.

ABSTRACT:

Study objectives

Changes in lymphocyte phenotype and functionality have been described in adult patients with obstructive sleep apnea (OSA). We hypothesized that OSA is associated with T lymphocyte alterations in children, particularly in T regulatory lymphocytes (T regs), and aimed to characterize circulating T lymphocyte subsets in children with OSA.

Design

Cross-sectional.

Setting

Kosair Children's Hospital (Louisville, KY, USA) and Comer Children's Hospital (Chicago, IL, USA).

Participants

Consecutively recruited children being evaluated for habitual snoring.

Interventions

N/A.

Measurements and results

Overnight polysomnography (PSG) was performed and a fasting blood sample was obtained from the patients. Flow cytometry was performed on periph

SUBMITTER: Tan HL 

PROVIDER: S-EPMC3648675 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature